The GESC’s mission is to empower its users with access to the most up-to-date technologies in the fields of gene editing and stem cells and enable the creation of research models best fit for the unique need of each lab.

Number of projects completed up to Jan 2022

  • # of gRNA validated: >5000
  • # of NGS samples processed: >10K
  • # of parental cancer cell and iPSC lines worked with: >150
  • # of engineered cancer and iPS cell lines: > 600
  • # of mouse models created with our help: >400
  •  # of iPSC reprogrammed: >200
  • # of patient tissue banked: >800
View a list of all publications by GESC lab members here

Publications Citing Our Services

2022
  • Yenkin, A., Bramley, J., Waligorski, J., Kremitzki, C., et al. Mitochondrial Phenotypes Distinguish Pathogenic MFN2 Mutations by Pooled Functional Genomics Screen. Research Square, Jan 24, 2022. DOI: https://doi.org/10.21203/rs.3.rs-1213835/v1
  • Matthew J. Rosene, Simon Hsu, Shih Feng You, Logan Brase, Anthony Verbeck, Rita Martinez, Clare E. Wallace, Zeran Li, Ping Yan, Nina M. Dräger, Sydney M. Sattler, Abhirami K Iyer, Shannon L Macauley, David M. Holtzman, Bruno A. Benitez, Martin Kampmann, Carlos Cruchaga, Oscar Harari, John R. Cirrito, Jin-Moo Lee, Alison M. Goate, Celeste M. Karch. Phospholipase D3 contributes to Alzheimer’s disease risk via disruption of Aβ clearance and microglia response to amyloid plaques. medRxiv 2022.01.31.22270175; doi: https://doi.org/10.1101/2022.01.31.22270175
  • Luke, C.J., Markovina, S., Good, M. et al. Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins. Commun Biol 5, 47 (2022). https://doi.org/10.1038/s42003-021-02953-x
  • Omachi, K., Kai, H., Roberge, M., Miner, JH. Full-length and split-NanoLuc reporters identify pathogenic Col4A5 nonsense mutations susceptible to premature termination codon readthrough. iScience, Feb 2022. https://doi.org/10.1016/j.isci.2022.103891
2021
  • Akter, Cui, Chen, Ding. Generation of two induced pluripotent stem cell lines with heterozygous and homozygous GAG deletion in TOR1A gene from a healthy hiPSC line. Stem Cell Research (56), Oct 2021, 102536. https://doi.org/10.1016/j.scr.2021.102536
  • Chen, Sasaki, DiAntonio, Milbrandt. SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration. Experimental Neurology (339), May 2021, 113636. https://doi.org/10.1016/j.expneurol.2021.113636
  • Dale R. Balce, Ya-Ting Wang, Michael R. McAllaster, Bria F. Dunlap, Anthony Orvedahl, Barry L. Hykes, Lindsay Droit, Scott A. Handley, Craig B. Wilen, John G. Doench, Robert C. Orchard, Christina L. Stallings, Herbert W. Virgin. UFMylation inhibits the proinflammatory capacity of interferon-γ–activated macrophages. Proceedings of the National Academy of Sciences Jan 2021, 118 (1) e2011763118; DOI: 10.1073/pnas.2011763118
  • Amanda R. Dicks, Grigory I. Maksaev, Zainab Harissa, Alireza Savadipour, Ruhang Tang, Nancy Steward, Wolfgang Liedtke, Colin G. Nichols, Chia-Lung Wu, Farshid Guilak. Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes. bioRxiv 2021.06.15.448562; doi: https://doi.org/10.1101/2021.06.15.448562
  • Kim MY, Cooper ML, Jacobs MT, Ritchey JK, Hollaway J, Fehniger TA, DiPersio JF. CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy. JCI Insight. 2021 Aug 23;6(16):e149819. doi: 10.1172/jci.insight.149819. PMID: 34423790; PMCID: PMC8410010.
  • Meganathan, K., Prakasam, R., Baldridge, D. et al. Altered neuronal physiology, development, and function associated with a common chromosome 15 duplication involving CHRNA7. BMC Biol 19, 147 (2021). https://doi.org/10.1186/s12915-021-01080-7
  • Mary Ellen Urick PhD, Eun-Jeong Yu PhD, Daphne W. Bell PhD. High-risk endometrial cancer proteomic profiling reveals that FBXW7 mutation alters L1CAM and TGM2 protein levels. Cancer (127.16) 19 April 2021 https://doi.org/10.1002/cncr.33567
  • Alexandre T. Vessoni, Tianpeng Zhang, Annabel Quinet, Ho-Chang Jeong, Michael Munroe, Matthew Wood, Enzo Tedone, Alessandro Vindigni, Jerry W. Shay, Roger A. Greenberg, Luis F.Z. Batista. Telomere erosion in human pluripotent stem cells leads to ATR-mediated mitotic catastrophe. J Cell Biol (2021) 220 (6): e202011014. https://doi.org/10.1083/jcb.202011014
  • Huang, X., Park, Km., Gontarz, P. et al. OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human. Nat Commun 12, 5123 (2021). https://doi.org/10.1038/s41467-021-25107-3
  • Kabir, A., Subramanian, M., Lee, DH., Wang, X., et al. Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity. Science Translational Medicine. 3 Mar 2021. Vol 13, Issue 583. DOI: 10.1126/scitranslmed.abb6731
  • McLellan LK, McAllaster MR, Kim AS, Tóthová Ľ, Olson PD, Pinkner JS, et al. (2021) A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis. PLoS Pathog 17(1): e1009314. https://doi.org/10.1371/journal.ppat.1009314
  • DeBaker, MC., Fernandez de Velasco, EM., McCall, NM., Lee, AM., Wickman, K. Differential Impact of Inhibitory G-Protein Signaling Pathways in Ventral Tegmental Area Dopamine Neurons on Behavioral Sensitivity to Cocaine and Morphine. eNeuro. 2021 Mar-Apr; 8(2): ENEURO.0081-21.2021. PMID: 33707203
  • Michael R. McAllaster, Jaya Bhushan, Dale R. Balce, Anthony Orvedahl, Arnold Park, Seungmin Hwang, Meagan E. Sullender, L. David Sibley, Herbert W. Virgin. Autophagy gene-dependent intracellular immunity triggered by interferon-γ. bioRxiv 2021.05.10.443539; doi: https://doi.org/10.1101/2021.05.10.443539
  • Chen, R., Okeyo-Owuor, T., Patel, RM., Casey, EB., Cluster, AS., Yang, W., Magee, JA. Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy. Cell Reports 34-7 (Feb 2021), 108751. https://doi.org/10.1016/j.celrep.2021.108751
  • Nie, J., Ueda, Y., Solivais, A., Hashino, E. CHD7 regulates otic lineage differentiation and deafness gene expression in human inner ear organoids. Research Square (Dec 2021). DOI: https://doi.org/10.21203/rs.3.rs-1132148/v1
  • Zhou, Y., Bennett, TM., Shiels, A. Mutation of the TRPM3 cation channel underlies progressive cataract development and lens calcification associated with pro-fibrotic and immune cell responses. The FASEB Journal, 35-2 (Feb 2021). https://doi.org/10.1096/fj.202002037R
  • McAllaster, MR. Investigation of IFNγ-induced Control of Intracellular Pathogens. PhD Thesis, Washington University in St Louis, August 2021.
  • Elvisa Mehinovic, Teddi Gray, Meghan Campbell, Jenny Ekholm, Aaron Wenger, William Rowell, Ari Grudo, Jane Grimwood, Jonas Korlach, Christina Gurnett, John N. Constantino, Tychele N. Turner. Germline mosaicism of a missense variant in KCNC2 in a multiplex family with autism and epilepsy. medRxiv 2021.12.06.21264306; doi: https://doi.org/10.1101/2021.12.06.21264306
  • Walker FC, Hassan E, Peterson ST, Rodgers R, Schriefer LA, Thompson CE, et al. (2021) Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid. PLoS Pathog 17(3): e1009402. https://doi.org/10.1371/journal.ppat.1009402
  • Collins, TB. Functional Interrogation of JAK2 and ASXL1 Mutations in Myeloproliferative Neoplasms. PhD Thesis, Washington University in St Louis, January 2021.
  • Kiriakos, EK., Steinberg, DF., Kluender, CE., et al. Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease. JCI Insight. 2021 Feb 22; 6(4): e136166. Published online 2021 Feb 22. doi: 10.1172/jci.insight.136166
  • Rie Asada Kitamura, Kristina G. Maxwell, Wenjuan Ye, Kelly Kries, Cris M Brown, Punn Augsornworawat, Yoel Hirsch, Martin M Johansson, Tzvi Weiden, Joseph Ekstein, Joshua Cohen, Justin Klee, Kent Leslie, Anton Simeonov, Mark J. Henderson, Jeffrey R. Millman, Fumihiko Urano. Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome. bioRxiv 2021.11.07.467657; doi: https://doi.org/10.1101/2021.11.07.467657
  • Hogrebe, N.J., Maxwell, K.G., Augsornworawat, P. et al. Generation of insulin-producing pancreatic β cells from multiple human stem cell lines. Nat Protoc 16, 4109–4143 (2021). https://doi.org/10.1038/s41596-021-00560-y
  • Wu, K., Kamimoto, K., Zhang, Y., Yang, K., et al. Basal epithelial stem cells cross an alarmin checkpoint for postviral lung disease. J Clin Invest. 2021;131(19):e149336. https://doi.org/10.1172/JCI149336.
  • Siqi Zhao, Zachary Pincus, Barak A Cohen. Modular effects of gene promoters and chromatin environments on noise in gene expression. bioRxiv 2021.04.29.441875; doi: https://doi.org/10.1101/2021.04.29.441875
  • Song J, Chow RD, Pena-Hernandez M, et al. LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry in trans. Preprint. bioRxiv. 2021;2021.11.23.469714. Published 2021 Nov 24. doi:10.1101/2021.11.23.469714
  • Onken, MD., Blumer, KJ., Cooper, JA. Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium. Molecular Biology of the Cell, Vol. 32, No. 5. https://doi.org/10.1091/mbc.E20-04-0241
  • Kannangara, AR., Poole, DM., McEwan, CM., Youngs, JC., et al. BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters. EMBO Reports (2021)22:e51136https://doi.org/10.15252/embr.202051136
  • Das, S., Marin, ND., Esaulova, E., et al. Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4+ T Cell Activation and Mycobacterium tuberculosis Control. mBio 12:4 (July 2021).  https://doi.org/10.1128/mBio.01468-21
  • Chen, J., Lambo, ME., Ge. X., et al. A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation. Neuron 109:23 (Dec 2021). https://doi.org/10.1016/j.neuron.2021.09.009
  • Clippinger, SR., Cloonan, PE., Wang, W., et al. Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin T drives cellular adaptation. Journal of General Physiology (2021), 153 (5): e202012787. https://doi.org/10.1085/jgp.202012787
  • Meganathan, K., Prakasam, R., Baldridge, D., et. al. Alterations in neuronal physiology, development, and function associated with a common duplication of chromosome 15 involving CHRNA7. BMC Biology 19:147 (2021). doi: 10.1186/s12915-021-01080-7
  • Robert N. Bone, Xin Tong, Staci A. Weaver, Charanya Muralidharan, Preethi Krishnan, Tatsuyoshi Kono, Carmella Evans-Molina. Loss of Secretory Pathway Ca2+ ATPase (SPCA1) Impairs Insulin Secretion and Reduces Autophagy in the Pancreatic Islet. bioRxiv 2021.08.30.458203; doi: https://doi.org/10.1101/2021.08.30.458203
  • Wollen, K.L., Hagen, L., Vågbø, C.B. et al. ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA. J Transl Med 19, 287 (2021). https://doi.org/10.1186/s12967-021-02948-6
  • Kabir, A. Etv2/Myct1 Axis in the Regulation of Tumor Angiogenesis and Anti-Tumor Immunity. PhD Thesis, Washington University in St Louis, May 2021.
  • Graziano, VR., Alfajaro, MM., Schmitz, CO., et al. CD300lf Conditional Knockout Mouse Reveals Strain-Specific Cellular Tropism of Murine Norovirus. Journal of Virology (2021). 95 (3), https://doi.org/10.1128/JVI.01652-20
  • Upegui, SR. Decoding the Roles of Neurexin-3a at the Synapse Using a Disease-Relevant Mutation. PhD Thesis, University of Colorado (Sept 2021).
  • Elliot, JL. Investigating the Integration-Independent Role of HIV-1 in In the Viral Life Cycle. PhD Thesis, Washington University in St Louis (Jan 2021).
  • Maxwell, KG. Autologous Stem Cell-Derived B Cells for Diabetes Cell Replacement Therapy. PhD Thesis, Washington University in St Louis (Jan 2021).
2020
  • Schulman, S., Turro, E., et. al. A coagulation defect arising from heterozygous premature termination of tissue factor. J Clin Invest. 2020;130(10):5302-5312. https://doi.org/10.1172/JCI133780.
  • Zhenyi Liu, John A. Schiel, Elena Maksimova, Žaklina Strezoska, Guojun Zhao, Emily M. Anderson, Yumei Wu, Joe Warren, Angela Bartels, Anja van Brabant Smith, Chris E. Lowe, and Kevin P. Forbes. ErCas12a CRISPR-MAD7 for Model Generation in Human Cells, Mice, and Rats. The CRISPR Journal. Apr 2020. 97-108. http://doi.org/10.1089/crispr.2019.0068
  • Maxwell, KG., Augsornworawat, P., Velazco-Cruz, L., et. al. Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice. Science Translational Medicine. 22 Apr 2020. Vol 12, Issue 540. DOI: 10.1126/scitranslmed.aax9106
  • Arthur S. Kim, Ofer Zimmerman, Julie M. Fox, Christopher A. Nelson, Katherine Basore, Rong Zhang, Lorellin Durnell, Chandni Desai, Christopher Bullock, Sharon L. Deem, Jonas Oppenheimer, Beth Shapiro, Ting Wang, Sara Cherry, Carolyn B. Coyne, Scott A. Handley, Michael J. Landis, Daved H. Fremont, Michael S. Diamond. An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. Cell Host & Microbe, Volume 27, Issue 3, 2020, Pages 428-440.e9. ISSN 1931-3128, https://doi.org/10.1016/j.chom.2020.01.008.
  • Nguyen, LD., Fischer, TT., et al. Calpain inhibitor and ibudilast rescue B cell functions in a cellular model of Wolfram syndrome.  PNAS July 21, 2020 117 (29) 17389-17398; first published July 6, 2020; https://doi.org/10.1073/pnas.2007136117
  • Silva-Fisher, JM., Dang, HX, White, NM., et. al. Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression. Nature Communications 11, 2156 (2020). https://doi.org/10.1038/s41467-020-15547-8
  • Esser, AK., Ross, MH., Fontana, F., et al. Nanotherapy delivery of c-myc inhibitor targets Protumor Macrophages and preserves Antitumor Macrophages in Breast Cancer. Theranostics. 2020; 10(17): 7510-7526. doi: 10.7150/thno.44523
  • Wambach, JA., Yang, P., Wegnet, DJ., et. al. Functional Genomics of ABCA3 Variants. American Journal of Respiratory Cell and Molecular Biology. 63 (4), 2020. https://doi.org/10.1165/rcmb.2020-0034MA
  • Urick, ME., Bell, DW. Proteomic profiling of FBXW7-mutant serous endometrial cancer cells reveals upregulation of PADI2, a potential therapeutic target. Cancer Medicine, 2020. https://doi.org/10.1002/cam4.3013
  • Grau, KR., Zhu, S., Peterson, ST., et al. The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type III interferon. Nature Microbiology, 5, 84-92 (2020). https://doi.org/10.1038/s41564-019-0602-7
  • Tsuji, S., Stevens, C., Zhang, F., et. al. Improving the efficiency of liver targeting rAAV-mediated homologous recombination using ribonucleotide reductase inhibitors. Research Square, 2020.  https://doi.org/10.21203/rs.3.rs-106148/v1
  • Ahmed, M., Thirunavukkarasu, S., Rosa, BA., et. al. Immune correlates of tuberculosis disease and risk translate across species. Science Translational Medicine, 12: 528 (2020). DOI: 10.1126/scitranslmed.aay0233
  • Berrien-Elliot, MM., Cashen, AF., Cubitt, CC., et. al. Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations with Response after Adoptive Immunotherapy for Leukemia. Cancer Discov (2020) 10 (12): 1854–1871. https://doi.org/10.1158/2159-8290.CD-20-0312
  • Quinet, A., Tirman, S., Jackson, J., et al. PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells. Molecular Cell, 77 (3): Feb 2020. https://doi.org/10.1016/j.molcel.2019.10.008
  • Bartleson, JM., Viehmann-Milam, AA., Donermeyer, DL., et al. Strength of tonic T cell receptor signaling instructs T follicular helper cell-fate decisions. Nature Immunology, 21, 1384-1396 (2020). https://doi.org/10.1038/s41590-020-0781-7
  • Grau, KR., Zhu, S., Peterson, ST., et. al. Commensal bacteria regulate regionalization of acute norovirus infection along the intestinal tract through bile acid-mediated priming of type III interferon. Nature Microbiology. 2020 Jan; 5(1): 84–92. doi: 10.1038/s41564-019-0602-7
  • Puro, RJ., Bouchlaka, MN., Hiebsch, RR., et. al. Development of AO-176, a Next-Generation Humanized Anti-CD47 Antibody with Novel Anticancer Properties and Negligible Red Blood Cell Binding. Molecular Cancer Therapeutics (2020) 19 (3): 835–846. https://doi.org/10.1158/1535-7163.MCT-19-1079
  • Kisaka, JK., Ratner, L., Kyei, GB. The Dual-Specificity Kinase DYRK1A Modulates the Levels of Cyclin L2 To Control HIV Replication in Macrophages. Journal of Virology, 94:6. https://doi.org/10.1128/JVI.01583-19
  • Clippinger, SR., Cloonan, PE., Wang, W., et al. Mechanical dysfunction induced by a hypertrophic cardiomyopathy mutation is the primary driver of cellular adaptation. bioRxiv 2020.05.04.067181; doi: https://doi.org/10.1101/2020.05.04.067181
  • Gunesch, JT., Dixon, AL., Ebrahim, TAM., et al. CD56 regulates human NK cell cytotoxicity through Pyk2. eLife 2020;9:e57346 DOI: 10.7554/eLife.57346
  • Wong, R. Generation and Utilization of Diverse Memory B Cells after Flavivirus Challenges. PhD Thesis, Washington University in St Louis, May 2020.
  • Xu, M. The Role of Shelterin Proteins in Telomeme DNA Protection and Regulation. PhD Thesis, Case Western Reserve University, May 2020.
  • Kim, AS. Structural and Functional Insights into Alphavirus-host Interactions. PhD Thesis, Washington University in St Louis, August 2020.
2019
  • Peterson, ST., Kennedy, EA., Brigleb, PH., et al. Disruption of Type III Interferon (IFN) Genes Ifnl2 and Ifnl3 Recapitulates Loss of the Type III IFN Receptor in the Mucosal Antiviral Response. Journal of Virology, 93-22 (2019). DOI: https://doi.org/10.1128/JVI.01073-19
  • Karch, CM., Kao, AW., Karydas, A., et al. A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. Stem Cell Reports, Vol 13, Issue 5, 12 Nov 2019. https://doi.org/10.1016/j.stemcr.2019.09.006
  • Zhang, R., Earnest, JT., Kim, AS., et al. Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila. Cell Reports, Vol 28, Issue 10, 3 Sept 2019. https://doi.org/10.1016/j.celrep.2019.07.105
  • Clippinger, SR., Cloonan, PE., Greenberg, L., et al. Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy. PNAS September 3, 2019 116 (36) 17831-17840; August 19, 2019; https://doi.org/10.1073/pnas.1910962116
  • Salemo, EE., Patel, SP., Marshall, A., et. al. Extrarenal Signs of Proximal Renal Tubular Acidosis Persist in Nonacidemic Nbce1b/c-Null Mice. JASN June 2019, 30 (6) 979-989; DOI: https://doi.org/10.1681/ASN.2018050545
  • Bastola, P., Bilkis, R., et al. Heterozygous mutations in valosin-containing protein (VCP) and resistance to VCP inhibitors. Scientific Reports volume 9, Article number: 11002 (2019). https://doi.org/10.1038/s41598-019-47085-9
  • Lewis, EMA., Meganathan, K., Baldridge, D., et al. Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons. Molecular Autism volume 10, Article number: 51 (2019). https://doi.org/10.1186/s13229-019-0306-0
  • Bowles, KR., Julia, TCW., et al. Reduced variability of neural progenitor cells and improved purity of neuronal cultures using magnetic activated cell sorting. PLoS One, 2019. https://doi.org/10.1371/journal.pone.0213374
  • Huang, LH., Zinselmeyer, BH., Chang, CH., et al. Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis. Cell Metabolism, Volume 29, Issue 2, 5 February 2019. https://doi.org/10.1016/j.cmet.2018.10.006
  • Makkar, S., Riehl, T., Chen, B., et al. Hyaluronic Acid Binding to TLR4 Promotes Proliferation and Blocks Apoptosis in Colon Cancer. Molecular Cancer Therapeutics (2019) 18 (12): 2446–2456. https://doi.org/10.1158/1535-7163.MCT-18-1225
  • Jones, RS., Tu, C., et al. Characterization and Proteomic-Transcriptomic Investigation of Monocarboxylate Transporter 6 Knockout Mice: Evidence of a Potential Role in Glucose and Lipid Metabolism. Molecular Pharmacology September 2019, 96 (3) 364-376; DOI: https://doi.org/10.1124/mol.119.116731
  • Wang, W., Allard, BA., Pottorf, TS, et. al. Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis. bioRxiv 803544; doi: https://doi.org/10.1101/803544
  • Vincentz, JW., Firulli, BA., Toolan, KP., et al. Variation in a Left Ventricle–Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function. Circulation Research. 2019; 125: 575-589. https://doi.org/10.1161/CIRCRESAHA.119.315313
  • Brenner, KA. A Noncanonical Function of the Telomerase RNA Component in Human Embryonic Stem Cells. PhD Thesis, Washington University in St Louis, 2019.
  • Hung, S. Genetic Determinants of Enhancer Activation in Human Colon Cancer Epigenomes. PhD Thesis, Case Western Reserve University, 2019.
2018
  • Waghulde, H., Cheng, X., Galla, S., et al. Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1. Hypertension. 2018;72:1125–1132. https://doi.org/10.1161/HYPERTENSIONAHA.118.11175
  • Kulkarni, HS., Elvington, ML., Perng, YC., et al. Intracellular C3 Protects Human Airway Epithelial Cells from Stress-associated Cell Death. American Journal of Respiratory Cell and Molecular Biology, 60:2 (2018). https://doi.org/10.1165/rcmb.2017-0405OC
  • Soto, F., Zhao, L., Kerschensteiner, D. Synapse maintenance and restoration in the retina by NGL2. eLife 2018;7:e30388 DOI: 10.7554/eLife.30388
  • Urick, ME., Bell, DW. In vitro effects of FBXW7 mutation in serous endometrial cancer: Increased levels of potentially druggable proteins and sensitivity to SI-2 and dinaciclib. Molecular Carcinogenesis, 2018. https://doi.org/10.1002/mc.22867
  • Victor, MB., Richner, M., Olsen, HE., et al. Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes. Nature Neuroscience volume 21, pages341–352 (2018). https://doi.org/10.1038/s41593-018-0075-7
  • Orchard, RC., Wilen, CB., Virgin, HW. Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection. Nature Microbiology volume 3, pages1109–1114 (2018). https://doi.org/10.1038/s41564-018-0221-8
  • Nicolae, CM., O’Connor, MJ., Constantin, D., Moldovan, GL. NFκB regulates p21 expression and controls DNA damage-induced leukemic differentiation. Oncogene volume 37, pages3647–3656 (2018). https://doi.org/10.1038/s41388-018-0219-y
  • Giera, S., Luo, R., Ying, Y., et al. Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. eLife 2018;7:e33385 DOI: 10.7554/eLife.33385
  • Soll, JM., Brickner, JR., Mudge, MC., Mosammaparast, N. RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage. CELL BIOLOGY| VOLUME 293, ISSUE 35, P13524-13533, AUGUST 2018. https://doi.org/10.1074/jbc.RA117.000114
  • Kono, T., Tong, X., Taleb, S., et al. Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell. Diabetes 2018;67(11):2293–2304. https://doi.org/10.2337/db17-1351
  • Kumar, P., Kuhlmann, FM., Chakraborty, S., et al. Enterotoxigenic Escherichia coli–blood group A interactions intensify diarrheal severity. J Clin Invest. 2018;128(8):3298-3311. https://doi.org/10.1172/JCI97659.
  • Yokoyama, CC., Baldridge, MT., Leung, DW., et al. LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens. IMMUNOLOGY| VOLUME 293, ISSUE 16, P6022-6038, APRIL 2018. https://doi.org/10.1074/jbc.RA117.001246
  • Shen, SQ. Novel Approaches to Studying the Effects of Cis-Regulatory Variants in the Central Nervous System. PhD Thesis, Washington University in St Louis (May 2018).
  • Herbert, AL. The Role of Actr10 in Nervous System Development and Disease. PhD Thesis, Washington University in St Louis (May 2018).
  • Lee, MY. Autophagy in Zellweger Syndrome Spectrum Disorder and Cancer. PhD Thesis, UT South Western Medical Center, 2018.
2017
  • Budde, JP., Martinez, R., Hsu, S., et al. Precision genome-editing with CRISPR/Cas9 in human induced pluripotent stem cells. bioRxiv 187377; doi: https://doi.org/10.1101/187377
  • Kurokawa, YK., Yin, RT., et al. Human Induced Pluripotent Stem Cell-Derived Endothelial Cells for Three-Dimensional Microphysiological Systems. Tissue Engineering Part C: Methods, Vol. 23, No. 8 (2017). https://doi.org/10.1089/ten.tec.2017.0133
  • Brickner, JR., Soll, JM., Lombardi, PM., et al. A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature, volume 551, pages 389–393 (2017). https://doi.org/10.1038/nature24484
  • Wen, Y., Liao, G., et al. A stable but reversible integrated surrogate reporter for assaying CRISPR/Cas9-stimulated homology-directed repair. METHODS AND RESOURCES| VOLUME 292, ISSUE 15, P6148-6162, APRIL 2017. https://doi.org/10.1074/jbc.M117.777722
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  • Walker, LJ., Summers, DW., et al. MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2. eLife 2017;6:e22540 DOI: 10.7554/eLife.22540
  • Kurokawa, Y. Development of in vitro Drug Screening Platforms Using Human Induced Pluripotent Stem Cell-Derived Cardiovascular Cells. PhD Thesis, Washington University in St Louis, Dec 2017.
  • Xi, C. Evidence for Non-Coding RNAs as Inherited Factors Influencing Cardiovascular Disease, Renal Disease and Tumorigenesis. PhD Thesis, University of Toledo, 2017.
  • McDonald, J. Designing Epigenome Editing Tools to Understand the Functional Role of DNA Methylation Changes in Cancer. PhD Thesis, Washington University in St Louis, August 2017.
  • Enright, JM. Molecular Mechanisms of Photoreceptor Diversification and Spectral Tuning. PhD Thesis, Washington University in St Louis, May 2017.
2016
  • McDonald, JI., Celik, H., et al. Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation. Biol Open (2016) 5 (6): 866–874. https://doi.org/10.1242/bio.019067
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2015
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  • Maktabi, MH. The Role of Reversible Palmitoylation in Regulating Diverse Biological Processes. PhD Thesis, Washington University in St Louis, August 2015.